EFFECT OF ANTIANDROGEN (CYPROTERONE-ACETATE) ON ACTION OF TESTOSTERONE ON BONE PROTEIN

被引：0
|
作者：
BROULIK, PD [1 ]
STARKA, L [1 ]
PACOVSKY, V [1 ]
机构：
[1] CHARLES UNIV, FAC GEN MED, MED CLIN 3, PRAGUE, CZECHOSLOVAKIA
来源：
ENDOCRINOLOGIA EXPERIMENTALIS | 1976年 / 10卷 / 03期
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D O I：
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中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The effect of castration, androgen and antiandrogen treatment on bone protein content of femoral diaphyses of male mice was investigated. Castration and administration of 2.5 mg of cyproterone acetate for 21 days significantly reduced the protein content of the bone. Testoserone fully compensated the bone protein depletion seen in castrates. Simultaneous administration of both cyproterone acetate and testosterone to castrates blocked the testosterone action. The mouse bone matrix is a highly androgen dependent tissue.
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页码：211 / 216
页数：6
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