HLA-G DELETION POLYMORPHISM AND PREECLAMPSIA ECLAMPSIA

Objective To investigate a HLA-G deletion polymorphism in pre-eclamptic pedigrees and the general population. Design A population association study of HLA-G genotypes from pre-eclamptic/eclamptic patients and control groups. Setting Analyses undertaken in the School of Biological Sciences, Macquarie University. Patients were from Royal Women's Hospital, Melbourne, and controls were from Westmead Hospital and Macquarie University, Sydney. Subjects One hundred and ninety-six individuals, consisting of 29 pre-eclamptic/eclamptic (PE/E) patients, 13 individuals born of a PE/E pregnancy, 46 blood relatives of PE/E patients, 21 husbands of PE/E patients, 25 women normotensive in first pregnancy, 15 husbands of women normotensive in first pregnancy and 47 staff and students of Macquarie University. Results Genotypic and gene frequencies were not significantly different in the seven groups examined. Conclusion There is no detectable relationship between susceptibility to pre-eclampsia or being born of a pre-eclamptic pregnancy and HLA-G genotype.