SPONTANEOUS RESOLUTION OF PREECLAMPSIA-RELATED THROMBOCYTOPENIA

Objective To observe the spontaneous resolution of pre-eclampsia-related thrombocytopenia. Design A retrospective study. Setting High Risk Pregnancy Unit, John Radcliffe Maternity Hospital, Oxford. Subjects Thirty women with pre-eclampsia complicated by the HELLP/ELLP syndrome who did not receive any specific treatment for their thrombocytopenia. Intervention Serial platelet counts throughout labour and the puerperium until the platelet counts returned to levels above 100 x 10(9)/l. Main outcome measures Time taken from delivery and platelet nadir for platelet counts to return to levels above 100 x 10(9)/l. The rate of recovery from the platelet nadir was measured by the slope of the serial platelet counts plotted against time. Results The mean time until platelet count exceeded 100 x 10(9)/l was 67 h (SD 25) after delivery and 44 h (SD 17) from the platelet nadir. All women had counts above 100 x 10(9)/l by 111 h after delivery, and by 88 h after the platelet nadir. Although the time to recovery appeared to depend on the degree of thrombocytopenia, the rate of resolution did not. Conclusion These data can be used as a guide by clinicians as to the expected time course for postpartum resolution of pre-eclampsia-related thrombocytopenia.