A TOTAL SYNTHESIS OF (-)-PHYSOSTIGMINE

被引：56

作者：

NODE, M

ITOH, A

MASAKI, Y

FUJI, K

机构：

[1] GIFU PHARMACEUT UNIV,GIFU 502,JAPAN

[2] KYOTO UNIV,INST CHEM RES,UJI,KYOTO 611,JAPAN

来源：

HETEROCYCLES | 1991年 / 32卷 / 09期

关键词：

D O I：

10.3987/COM-91-5814

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A total synthesis of (-)-physostigmine (7) was accomplished from a chiral nitro olefin (1).

引用

页码：1705 / 1707

页数：3

共 19 条

[1] DAVIS KL, 1982, AM J PSYCHIAT, V139, P1421
[2] FUJI K, 1991, CHEM PHARM BULL, V39, P202, DOI 10.1248/cpb.39.202
[3] ASYMMETRIC INDUCTION VIA ADDITION ELIMINATION PROCESS - NITROOLEFINATION OF ALPHA-SUBSTITUTED LACTONES
FUJI, K
NODE, M
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NANIWA, Y
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[4] ADDITION-ELIMINATION STRATEGY FOR ASYMMETRIC INDUCTION - A CHIRAL SULFOXIDE AS A LEAVING GROUP
FUJI, K
NODE, M
ABE, H
ITOH, A
MASAKI, Y
SHIRO, M
[J]. TETRAHEDRON LETTERS, 1990, 31 (17) : 2419 - 2422
[5] DIRECT ASYMMETRIC-SYNTHESIS OF QUATERNARY CARBON CENTERS VIA ADDITION ELIMINATION PROCESS - NITROOLEFINATION OF ALPHA-SUBSTITUTED DELTA-LACTONES
FUJI, K
NODE, M
NAGASAWA, H
NANIWA, Y
TAGA, T
MACHIDA, K
SNATZKE, G
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (20) : 7921 - 7925
[6] Studies in the indole series. V. The complete synthesis of physostigmine (eserine)
Julian, PL
Pikl, J
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1935, 57 (01) : 755 - 757
[7] KIKUGAWA Y, 1981, CHEM PHARM BULL, V29, P1231
[8] ASYMMETRIC ALKYLATION OF OXINDOLES - AN APPROACH TO THE TOTAL SYNTHESIS OF (-)-PHYSOSTIGMINE
LEE, TBK
WONG, GSK
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (02) : 872 - 875
[9] GENERAL ENTRY TO THE SYNTHESIS OF OPTICALLY-ACTIVE DITERPENOIDS OF C-20-BETA SERIES
NODE, M
HAO, XJ
NAGASAWA, H
FUJI, K
[J]. TETRAHEDRON LETTERS, 1989, 30 (31) : 4141 - 4144
[10] A CHIRAL TOTAL SYNTHESIS OF (-)-PHYSOSTIGMINE
NODE, M
HAO, X
FUJI, K
[J]. CHEMISTRY LETTERS, 1991, (01) : 57 - 60

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