OPTIMAL-DESIGN FOR MODEL DISCRIMINATION USING THE F-TEST WITH NON-LINEAR BIOCHEMICAL-MODELS - CRITERIA FOR CHOOSING THE NUMBER AND SPACING OF EXPERIMENTAL POINTS

被引：33

作者：

BARDSLEY, WG ^{[1
]}

MCGINLAY, PB ^{[1
]}

ROIG, MG ^{[1
]}

机构：

[1] UNIV SALAMANCE,FAC FARM,DEPT QUIM FIS,E-37080 SALAMANCA,SPAIN

来源：

JOURNAL OF THEORETICAL BIOLOGY | 1989年 / 139卷 / 01期

关键词：

D O I：

10.1016/S0022-5193(89)80059-1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：85 / 102

页数：18

共 10 条

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[2] CONDITIONS WHEN STATISTICAL TESTS FOR MODEL DISCRIMINATION HAVE HIGH-POWER - SOME EXAMPLES FROM PHARMACOKINETICS, LIGAND-BINDING, TRANSIENT AND STEADY-STATE ENZYME-KINETICS [J].

BARDSLEY, WG ;

MCGINLAY, PB ;

ROIG, MG .

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[3] THE USE OF NONLINEAR REGRESSION-ANALYSIS AND THE F-TEST FOR MODEL DISCRIMINATION WITH DOSE-RESPONSE CURVES AND LIGAND-BINDING DATA [J].

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MCGINLAY, PB .

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[4]

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[5] USE OF THE F-TEST FOR DETERMINING THE DEGREE OF ENZYME-KINETIC AND LIGAND-BINDING DATA - A MONTE-CARLO SIMULATION STUDY [J].

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BARDSLEY, WG .

BIOCHEMICAL JOURNAL, 1983, 211 (01) :23-34

[6]

ENDRENYI L, 1981, KINETIC DATA ANAL

[7]

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[8]

Fedorov V., 1972, THEORY OPTIMAL EXPT

[9] A QUADRATIC DESIGN CRITERION FOR PRECISE ESTIMATION IN NONLINEAR-REGRESSION MODELS [J].

HAMILTON, DC ;

WATTS, DG .

TECHNOMETRICS, 1985, 27 (03) :241-250

[10]

Silvey SD., 1980, OPTIMAL DESIGN, DOI 10.1007/978-94-009-5912-5

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