FIBROBLAST GROWTH-FACTORS - AT THE HEART OF ANGIOGENESIS

被引：166
作者：
SLAVIN, J
机构：
[1] Department of Surgery, Aintree Hospitals, Liverpool
来源：
CELL BIOLOGY INTERNATIONAL | 1995年 / 19卷 / 05期
关键词：
D O I：
10.1006/cbir.1995.1087
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Acidic fibroblast growth factor (FGF-1) and basic fibroblast growth factor (FGF-2) are ubiquitous cytokines found in many tissues. They have effects on multiple cell types derived from mesoderm and neuroectoderm, including endothelial cells. lit this review the structure and function of the fibroblast growth factor family and its receptors are described. The evidence implicating bath FGF-1 and FGF-2 in the control of blood vessel formation is presented and their involvement in normal and pathological angiogenesis during adult life is then described in more detail.
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页码：431 / 444
页数：14
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