A SYNTHETIC PEPTIDE METALLOPROTEINASE INHIBITOR, BUT NOT TIMP, PREVENTS THE BREAKDOWN OF PROTEOGLYCAN WITHIN ARTICULAR-CARTILAGE INVITRO

被引：45
作者：
ANDREWS, HJ
PLUMPTON, TA
HARPER, GP
CAWSTON, TE
机构：
[1] ADDENBROOKES HOSP, RHEUMATOL RES UNIT, CAMBRIDGE CB2 2QQ, ENGLAND
[2] SMITHKLINE BEECHAM PHARMACEUT, HARLOW, ENGLAND
来源：
AGENTS AND ACTIONS | 1992年 / 37卷 / 1-2期
关键词：
D O I：
10.1007/BF01987904
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
IL1-stimulated pig articular cartilage fragments were cultured in the presence and absence of various metalloproteinase inhibitors. Tissue inhibitor of metalloproteinases (TIMP) was unable to stop the release of proteoglycan from the cartilage. Incubation of cartilage with a potent synthetic metalloproteinase inhibitor inhibited the release of proteoglycan in a dose-dependent fashion. The results suggest that low-M(r) metalloproteinase inhibitors may have therapeutic potential in limiting connective tissue breakdown in conditions such as rheumatoid arthritis.
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收藏
页码：147 / 154
页数：8
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