IMMUNOCYTOCHEMICAL STUDY OF NA(+) K+-ATPASE ALPHA-1 AND BETA-1 SUBUNITS IN HUMAN AND RAT NORMAL HEPATOCYTES USING CONFOCAL MICROSCOPY

被引：0

作者：

BENKOEL, L

BENOLIEL, AM

BRISSE, J

SASTRE, B

BONGRAND, P

CHAMLIAN, A

机构：

[1] HOP ST MARGUERITE, IMMUNOL LAB, F-13274 MARSEILLE 09, FRANCE

[2] HOP ST MARGUERITE, SERV CHIRURG DIGEST, F-13274 MARSEILLE 09, FRANCE

来源：

CELLULAR AND MOLECULAR BIOLOGY | 1995年 / 41卷 / 04期

关键词：

NA+ K+-ATPASE; ALPHA-1; SUBUNIT; BETA-1; HEPATOCYTE; IMMUNOCYTOCHEMISTRY; CONFOCAL MICROSCOPY;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatic Na+K+-ATPase was recently shown to be composed of two alpha 1 and beta 1 subunits similar to that of kidney. Its localization on hepatocyte plasma membranes was not; clearly established. We have studied the localization of alpha 1 and beta 1 subunits using immunocytochemical method and confocal microscopy. In accordance with previous cytochemical findings, the catalytic al subunit was distributed in basolateral and bile canalicular membranes of hepatocytes. The beta 1 subunit was not demonstrated, due to its very low amount in the liver. The controversy about the bile canalicular localization was discussed.

引用

页码：499 / 504

页数：6