Feedback regulation of mitochondrial homeostasis via Wnt/beta-catenin signaling

被引：10
作者：
Bernkopf, Dominic B. [1 ]
Behrens, Juergen [1 ]
机构：
[1] Friedrich Alexander Univ Erlangen Nuremberg, Nikolaus Fiebiger Ctr, Expt Med 2, Erlangen, Germany
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2018年 / 5卷 / 03期
关键词：
beta-catenin; AXIN1; PGAM5; mitochondria; Wnt signaling;
D O I：
10.1080/23723556.2018.1458015
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cellular abundance of mitochondria is dynamically regulated. We could recently show that dysfunctional mitochondria release the phosphatase PGAM family member 5 (PGAM5) into the cytosol, where it interacts with the Wnt signaling-component AXIN1 and dephosphorylates AXIN1 -bound /J-catenin (CTNNB1) thereby activating Wnt/beta-catenin signaling. Because Wnt/beta-catenin signaling induces mitochondrial biogenesis dysfunctional mitochondria trigger their own replacement by releasing PGAM5.
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页数：2
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