Phase-locking of epileptic spikes to ongoing delta oscillations in non-convulsive status epilepticus

被引：3

作者：

Hindriks, Rikkert ^{[1
,2
]}

Meijer, Hil G. E. ^{[3
]}

van Gils, Stephan A. ^{[3
]}

van Putten, Michel J. A. M. ^{[1
,4
]}

机构：

[1] Univ Twente, MIRA Inst Biomed Technol & Tech Med, Dept Clin Neurophysiol, Enschede, Netherlands

[2] Univ Pompeu Fabra, Ctr Brain & Cognit, Dept Informat & Commun Technol, Computat Neurosci Grp, Roc Boronat 138, Barcelona 08018, Spain

[3] Univ Twente, MIRA Inst Biomed Technol & Tech Med, Dept Elect Engn Math & Comp Sci, Enschede, Netherlands

[4] Medisch Spectrum Twente, Dept Neurol & Clin Neurophysiol, Enschede, Netherlands

来源：

FRONTIERS IN SYSTEMS NEUROSCIENCE | 2013年 / 7卷

关键词：

absence status; delta oscillation; absence seizure; spike-wave discharge; phase-locking; thalamo-cortical system;

D O I：

10.3389/fnsys.2013.00111

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The EEG of patients in non-convulsive status epilepticus (NCSE) often displays delta oscillations or generalized spike-wave discharges. In some patients, these delta oscillations coexist with intermittent epileptic spikes. In this study we verify the prediction of a computational model of the thalamo-cortical system that these spikes are phase-locked to the delta oscillations. We subsequently describe the physiological mechanism underlying this observation as suggested by the model. It is suggested that the spikes reflect inhibitory stochastic fluctuations in the input to thalamo-cortical relay neurons and phase-locking is a consequence of differential excitability of relay neurons over the delta cycle. Further analysis shows that the observed phase-locking can be regarded as a stochastic precursor of generalized spike-wave discharges. This study thus provides an explanation of intermittent spikes during delta oscillations in NCSE and might be generalized to other encephathologies in which delta activity can be observed.

引用

页数：10