AMINO-ACIDS AND PEPTIDES .16. SYNTHESIS OF N-TERMINAL TETRAPEPTIDE ANALOGS OF FIBRIN ALPHA-CHAIN AND THEIR INHIBITORY EFFECTS ON FIBRINOGEN THROMBIN CLOTTING

被引：17

作者：

KAWASAKI, K ^{[1
]}

HIRASE, K ^{[1
]}

MIYANO, M ^{[1
]}

TSUJI, T ^{[1
]}

IWAMOTO, M ^{[1
]}

机构：

[1] DAIICHI SEIYAKU CO LTD, RES INST, EDOGAWA KU, TOKYO 134, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 12期

关键词：

PEPTIDE SYNTHESIS; ACTIVE ESTER; FIBRIN ALPHA-CHAIN; ANTICOAGULANT; FIBRINOGEN THROMBIN CLOTTING;

D O I：

10.1248/cpb.40.3253

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N-Terminal tetrapeptide analog, of fibrin alpha-chain were synthesized by the solution method using a new active ester, the ester of the oxime of p-nitroacetophenone, and by the solid-phase method. Their inhibitory effects on fibrinogen/thrombin clotting were examined. Of the synthetic peptides, amide analogs of Gly-Pro-Arg-Pro exhibited a more potent inhibitory effect.

引用

页码：3253 / 3260

页数：8

共 3 条

[1] AMINO-ACIDS AND PEPTIDES .17. SYNTHESIS OF PEPTIDES RELATED TO N-TERMINAL PORTION OF FIBRIN ALPHA-CHAIN AND THEIR INHIBITORY EFFECT ON FIBRINOGEN THROMBIN CLOTTING
KAWASAKI, K
TSUJI, T
HIRASE, K
MIYANO, M
INOUYE, S
IWAMOTO, M
CHEMICAL & PHARMACEUTICAL BULLETIN, 1993, 41 (03) : 525 - 528
[2] AMINO-ACIDS AND PEPTIDES .18. SYNTHETIC PEPTIDES RELATED TO N-TERMINAL PORTION OF FIBRIN ALPHA-CHAIN AND THEIR INHIBITORY EFFECT ON FIBRINOGEN THROMBIN CLOTTING
KAWASAKI, K
MIYANO, M
HIRASE, K
IWAMOTO, M
CHEMICAL & PHARMACEUTICAL BULLETIN, 1993, 41 (05) : 975 - 977
[3] AMINO-ACIDS AND PEPTIDES .13. SYNTHETIC STUDIES ON N-TERMINAL TRIPEPTIDE AMIDE ANALOGS OF FIBRIN ALPHA-CHAIN
KAWASAKI, K
TSUJI, T
HIRASE, K
MIYANO, M
IMOTO, Y
IWAMOTO, M
CHEMICAL & PHARMACEUTICAL BULLETIN, 1991, 39 (03) : 584 - 589

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