SEQUENCE DISCRIMINATION BY ALTERNATIVELY SPLICED ISOFORMS OF A DNA-BINDING ZINC FINGER DOMAIN

被引:92
作者
GOGOS, JA
HSU, T
BOLTON, J
KAFATOS, FC
机构
[1] HARVARD UNIV,DEPT CELLULAR & DEV BIOL,CAMBRIDGE,MA 02138
[2] UNIV CRETE,FORTH,INST MOLEC BIOL & BIOTECHNOL,GR-71110 IRAKLION,GREECE
[3] UNIV CRETE,DEPT BIOL,GR-71110 IRAKLION,GREECE
关键词
D O I
10.1126/science.1290524
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Two major developmentally regulated isoforms of the Drosophila chorion transcription factor CF2 differ by an extra zinc finger within the DNA binding domain. The preferred DNA binding sites were determined and are distinguished by an internal duplication of TAT in the site recognized by the isoform with the extra finger. The results are consistent with modular interactions between zinc fingers and trinucleotides and also suggest rules for recognition of AT-rich DNA sites by zinc finger proteins. The results show how modular finger interactions with trinucleotides can be used, in conjunction with alternative splicing, to alter the binding specificity and increase the spectrum of sites recognized by a DNA binding domain. Thus, CF2 may potentially regulate distinct sets of target genes during development.
引用
收藏
页码:1951 / 1955
页数:5
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