IDENTIFICATION OF AN S-ANTIGEN-LIKE MOLECULE IN DROSOPHILA-MELANOGASTER - AN IMMUNOHISTOCHEMICAL STUDY

被引:9
作者
LIEB, WE
SMITHLANG, L
SINGHDUA, H
CHRISTENSEN, AC
DONOSO, LA
机构
[1] WILLS EYE HOSP & RES INST,RES DEPT,RETINA SERV,9TH & WALNUT ST,PHILADELPHIA,PA 19107
[2] THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DEPT BIOCHEM & MOLEC BIOL,PHILADELPHIA,PA 19107
[3] ALCON LABS INC,FT WORTH,TX 76101
关键词
COMPOUND EYE; DROSOPHILA-MELANOGASTER; IMMUNOHISTOCHEMISTRY; MONOCLONAL ANTIBODY; S-ANTIGEN; VISION;
D O I
10.1016/0014-4835(91)90071-L
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Vision is a highly complex process common to many vertebrate and invertebrate species. The visual system of Drosophila represents a valuable model in which to study this process since its chromosomal makeup has been well mapped and many mutants containing specific photoreceptor defects have been described. S-antigen is a well-characterized photoreceptor cell protein which plays a fundamental role in the visual process. In this study, we used a panel of four monoclonal antibodies (MAbs) specific for amino, mid and carboxy terminal amino acid sequences in S-antigen in order to examine S-antigen immunoreactivity in the Drosophila visual system. Two MAbs, MAb 5C6.47 and MAbC10-C10, localized S-antigen to the retinules and ocelli. In contrast, MAbA2-G5 and MAbA9-C6 did not stain. The presence and strong antigenic similarity of an S-antigen homolog in Drosophila suggests that in both vertebrates and invertebrates S-antigen plays a major role in the regulation of the phototransduction of vision. © 1991.
引用
收藏
页码:171 / 178
页数:8
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