CHROMOSOMAL LOCALIZATION OF THE GASTRIC AND BRAIN RECEPTORS FOR CHOLECYSTOKININ (CCKAR AND CCKBR) IN HUMAN AND MOUSE

被引：38

作者：

HUPPI, K ^{[1
]}

SIWARSKI, D ^{[1
]}

PISEGNA, JR ^{[1
]}

WANK, S ^{[1
]}

机构：

[1] NIDDK,DIGEST DIS BRANCH,BETHESDA,MD 20892

来源：

GENOMICS | 1995年 / 25卷 / 03期

关键词：

D O I：

10.1016/0888-7543(95)80018-H

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Receptors for cholcystokinin (CCK) can be pharmacologically classified into at least two distinct subtypes, CCK(A)R and CCK(B)R. In an effort to determine whether the CCKA and CCKB receptors may be associated with certain CNS or gastrointestinal diseases, we have localized and compared the human and mouse chromosomal loci encoded by the CCKAR and CCKBR genes. The gene encoding the CCKA receptor maps to a syntenic region of human chromosome 4 and mouse chromosome 5. The CCKB receptor gene, on the other hand, resides on a syntenic region of human chromosome 11 and distal mouse chromosome 7. Localization of the CCK receptors with two dopamine receptors, DRD5 (4p15.1-p15.3) and DRD4 (11p15), provides the interesting possibility of coinvolvement in neuropsychiatric or CNS illnesses. (C) 1995 Academic Press, Inc.

引用

页码：727 / 729

页数：3

共 25 条

[1] BIOCHEMICAL AND PHARMACOLOGICAL CHARACTERIZATION OF AN EXTREMELY POTENT AND SELECTIVE NONPEPTIDE CHOLECYSTOKININ ANTAGONIST [J].