DETECTION OF A HUMAN INTRACISTERNAL RETROVIRAL PARTICLE ASSOCIATED WITH CD4+ T-CELL DEFICIENCY

被引:60
作者
GUPTA, S
RIBAK, CE
GOLLAPUDI, S
KIM, CH
SALAHUDDIN, SZ
机构
[1] UNIV CALIF IRVINE,DEPT ANAT & NEUROBIOL,IRVINE,CA 92717
[2] UNIV SO CALIF,SCH MED,DEPT MED,LOS ANGELES,CA 90033
关键词
PNEUMOCYSTIS-CARINII PNEUMONIA; HUMAN IMMUNODEFICIENCY VIRUS-NEGATIVE AIDS;
D O I
10.1073/pnas.89.16.7831
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A number of non-human-immunodeficiency-virus (HIV) type 1 disorders are associated with CD4+ T-cell deficiency and dysfunction. However, the etiopathogenesis of CD4+ T-cell immunodeficiency in these disease states remains unclear. Human intracisternal retroviral (HICRV) particles were detected in a lymphoblastoid cell line exposed to mononuclear cells from a patient with severe CD4+ T-cell deficiency without risk factors for HIV infection. Ultrastructurally, the HICRV is distinct from HIV-1, HIV-2, human T-lymphotropic virus (HTLV) type I, and HTLV-II. Supernatants of activated mononuclear cells showed significant reverse transcriptase activity that was predominantly Mn2+ dependent. The patient's mononuclear cells were negative for HIV-1, HIV-2, HTLV-I, and HTLV-II proviruses as demonstrated by the lack of amplification by PCR. Also, the patient's serum was negative for antibodies to HIV-1, HTLV-I, and HTLV-II and for HIV-1 p24 antigen; however, serum was positive for antibodies against the HICRV as demonstrated by Western blot. Similar HICRV particles were detected in a lymphoblastoid cell line exposed to mononuclear cells from the patient's daughter, who showed CD4+ T-cell dysfunction. The HICRV may be associated with CD4+ T-cell immunodeficiency and dysfunction in patients without risk for HIV-1, HIV-2, HTLV-I, and HTLV-II.
引用
收藏
页码:7831 / 7835
页数:5
相关论文
共 25 条
[1]  
ALKASSAB AS, 1990, CLIN EXP IMMUNOL, V81, P267
[2]   ISOLATION OF A T-LYMPHOTROPIC RETROVIRUS FROM A PATIENT AT RISK FOR ACQUIRED IMMUNE-DEFICIENCY SYNDROME (AIDS) [J].
BARRESINOUSSI, F ;
CHERMANN, JC ;
REY, F ;
NUGEYRE, MT ;
CHAMARET, S ;
GRUEST, J ;
DAUGUET, C ;
AXLERBLIN, C ;
VEZINETBRUN, F ;
ROUZIOUX, C ;
ROZENBAUM, W ;
MONTAGNIER, L .
SCIENCE, 1983, 220 (4599) :868-871
[3]   THE POSTVIRAL FATIGUE SYNDROME - AN ANALYSIS OF THE FINDINGS IN 50 CASES [J].
BEHAN, PO ;
BEHAN, WMH ;
BELL, EJ .
JOURNAL OF INFECTION, 1985, 10 (03) :211-222
[4]   CLINICAL AND IMMUNOLOGICAL ANALYSES OF 103 PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY [J].
CUNNINGHAMRUNDLES, C .
JOURNAL OF CLINICAL IMMUNOLOGY, 1989, 9 (01) :22-33
[5]   CYTOKINE-INDUCED EXPRESSION OF HIV-1 IN A CHRONICALLY INFECTED PROMONOCYTE CELL-LINE [J].
FOLKS, TM ;
JUSTEMENT, J ;
KINTER, A ;
DINARELLO, CA ;
FAUCI, AS .
SCIENCE, 1987, 238 (4828) :800-802
[6]   DETECTION OF A HUMAN INTRACISTERNAL A-TYPE RETROVIRAL PARTICLE ANTIGENICALLY RELATED TO HIV [J].
GARRY, RF ;
FERMIN, CD ;
HART, DJ ;
ALEXANDER, SS ;
DONEHOWER, LA ;
HONG, LZ .
SCIENCE, 1990, 250 (4984) :1127-1129
[7]   UNEXPLAINED CD4-POSITIVE T-CELL DEFICIENCY IN NON-HIV PATIENTS PRESENTING AS A PNEUMOCYSTIS-CARINII PNEUMONIA [J].
GAUTIER, V ;
CHANEZ, P ;
VENDRELL, JP ;
PUJOL, JL ;
LACOSTE, JY ;
DEFAUCAL, H ;
GODARD, P ;
MICHEL, FB .
CLINICAL AND EXPERIMENTAL ALLERGY, 1991, 21 (01) :63-66
[8]   DEFICIENT AUTOLOGOUS MIXED LYMPHOCYTE-REACTION IN KAPOSIS SARCOMA ASSOCIATED WITH DEFICIENCY OF LEU-3+ RESPONDER T-CELLS [J].
GUPTA, S ;
SAFAI, B .
JOURNAL OF CLINICAL INVESTIGATION, 1983, 71 (02) :296-300
[9]   INFECTION OF HTLV-III/LAV IN HTLV-I-CARRYING CELLS MT-2 AND MT-4 AND APPLICATION IN A PLAQUE-ASSAY [J].
HARADA, S ;
KOYANAGI, Y ;
YAMAMOTO, N .
SCIENCE, 1985, 229 (4713) :563-566
[10]   A CLUSTER OF PNEUMOCYSTIS-CARINII PNEUMONIA IN ADULTS WITHOUT PREDISPOSING ILLNESSES [J].
JACOBS, JL ;
LIBBY, DM ;
WINTERS, RA ;
GELMONT, DM ;
FRIED, ED ;
HARTMAN, BJ ;
LAURENCE, J .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (04) :246-250