PREVALENCE OF MICROALBUMINURIA IN A LARGE POPULATION OF PATIENTS WITH MILD TO MODERATE ESSENTIAL-HYPERTENSION

被引:153
作者
BIGAZZI, R [1 ]
BIANCHI, S [1 ]
CAMPESE, VM [1 ]
BALDARI, G [1 ]
机构
[1] UNIV SO CALIF,DIV NEPHROL,LOS ANGELES,CA 90089
来源
NEPHRON | 1992年 / 61卷 / 01期
关键词
MICROALBUMINURIA; ESSENTIAL HYPERTENSION; RENAL FUNCTION;
D O I
10.1159/000186842
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
To determine the prevalence of increased urinary albumin excretion (UAE) in essential hypertension and to establish whether this abnormality is associated with deranged renal function, we have measured UAE in a group of 123 patients with essential hypertension and in 110 normal subjects. Mean arterial pressure (MAP) was 96 +/- 0.6 mm Hg in normal subjects and 121 +/- 0.3 mm Hg in patients with essential hypertension (p < 0.01). Mean UAE was 8.6 +/- 0.5 in normal subjects and 32.9 +/- 3.3 mg/24 h in patients with essential hypertension (p < 0.01). Forty percent of patients with essential hypertension manifested a UAE exceeding 30 mg/24 h and had an average UAE of 72.0 +/- 4.7 mg/24 h. MAP in patients with increased UAE was similar to that in subjects with normal UAE (121 +/- 0.5 vs. 121 +/- 0.4 mm Hg). Creatinine clearance was also not different between these two groups (91 +/- 1.8 vs. 94 +/- 1.5 ml/min). No correlation was found between UAE and MAP or creatinine clearance. Long-term prospective studies are needed to extablish whether an increase in UAE may predict future nephrosclerosis in essential hypertension.
引用
收藏
页码:94 / 97
页数:4
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