Dual trigger with gonadotropin-releasing hormone and human chorionic gonadotropin for poor responders

被引：14

作者：

Eser, Ahmet ^{[1
]}

Devranoglu, Belgin ^{[1
]}

Ergen, Evrim Bostanci ^{[1
]}

Abide, Cigdem Yayla ^{[1
]}

机构：

[1] Istanbul Zeynep Kamil Woman & Child Dis Training, Dept Gynecol Obstet & Reprod Med, Istanbul, Turkey

来源：

JOURNAL OF THE TURKISH-GERMAN GYNECOLOGICAL ASSOCIATION | 2018年 / 19卷 / 02期

关键词：

Dual trigger; intracytoplasmic sperm injection; poor responders;

D O I：

10.4274/jtgga.2017.0045

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To compare metaphase II (MII) rate, fertilization rate, and embryo quality with dual trigger gonadotropin-releasing hormone agonist (GnRH) and normal dose human chorionic gonadotropin (hCG) versus a normal dose hCG trigger in antagonist intracytoplasmic sperm injection (ICSI) cycles of poor ovarian responders. Material and Methods: Patients defined as poor ovarian responders according to the Bologna criteria who underwent ICSI with GnRH antagonist protocol and triggered with dual trigger or hCG alone for oocyte maturation. Main outcome measures were MII rate, fertilization rate, and embryo quality. Results: Total gonadotropin doses and E-2 levels on trigger day were higher in the hCG trigger group. There were no significant differences with regard to implantation rate (p=0.304), biochemical pregnancy rate (p=0.815), clinical pregnancy rate (p=0.378), and ongoing pregnancy rate (p=0.635) between the groups. Conclusion: Dual trigger of oocyte maturation with GnRH agonist and normal dose hCG in poor responders does not demonstrate improved oocyte maturation, clinical pregnancy, and ongoing pregnancy rates.

引用

页码：98 / 103

页数：6

共 29 条

[1] Serum inhibin A, VEGF and TNFα levels after triggering oocyte maturation with GnRH agonist compared with HCG in women with polycystic ovaries undergoing IVF treatment:: a prospective randomized trial [J].