Improvements in 1,3-dipolar cycloaddition of nitrones to fluorinated dipolarophiles under solvent-free microwave activation

被引：30

作者：

Loupy, A ^{[1
]}

Petit, A ^{[1
]}

BonnetDelpon, D ^{[1
]}

机构：

[1] CTR ETUD PHARMACEUT,BIOCIS,SYNTH ORGAN LAB,CNRS,F-92296 CHATENAY MALABRY,FRANCE

来源：

JOURNAL OF FLUORINE CHEMISTRY | 1995年 / 75卷 / 02期

关键词：

dipolar cycloaddition; nitrones; fluorinated dipolarophiles; microwave activation; solvent-free conditions;

D O I：

10.1016/0022-1139(95)03330-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

1,3-Dipolar cycloadditions between ethyl trifluoracetoacetate or alpha-trifluoromethylstyrene and N-(benzylidene) methylamine N-oxide were performed in the absence of solvent. Under microwave irradiation in a monomode Maxidigest Prolabo reactor, quantitative yields were obtained within 3 min. Compared to conventional heating under the same conditions, the yields are significantly increased (from 55%-64% to 88.98%). Classical conditions using boiling toluene (65% within 24-48 h) are now considerably improved.

引用

页码：215 / 216

页数：2

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