Improvements in 1,3-dipolar cycloaddition of nitrones to fluorinated dipolarophiles under solvent-free microwave activation

被引：30
|
作者：
Loupy, A [1 ]
Petit, A [1 ]
BonnetDelpon, D [1 ]
机构：
[1] CTR ETUD PHARMACEUT,BIOCIS,SYNTH ORGAN LAB,CNRS,F-92296 CHATENAY MALABRY,FRANCE
来源：
JOURNAL OF FLUORINE CHEMISTRY | 1995年 / 75卷 / 02期
关键词：
dipolar cycloaddition; nitrones; fluorinated dipolarophiles; microwave activation; solvent-free conditions;
D O I：
10.1016/0022-1139(95)03330-6
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
1,3-Dipolar cycloadditions between ethyl trifluoracetoacetate or alpha-trifluoromethylstyrene and N-(benzylidene) methylamine N-oxide were performed in the absence of solvent. Under microwave irradiation in a monomode Maxidigest Prolabo reactor, quantitative yields were obtained within 3 min. Compared to conventional heating under the same conditions, the yields are significantly increased (from 55%-64% to 88.98%). Classical conditions using boiling toluene (65% within 24-48 h) are now considerably improved.
引用
收藏
页码：215 / 216
页数：2
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