STEADY-STATE PHARMACOKINETICS OF PIROXICAM IN CHILDREN WITH RHEUMATIC DISEASES

被引：11
作者：
MAKELA, AL
OLKKOLA, KT
MATTILA, MJ
机构：
[1] UNIV HELSINKI,DEPT CLIN PHARMACOL,SF-00170 HELSINKI 17,FINLAND
[2] UNIV TURKU,CENT HOSP,DEPT PEDIAT,SF-20520 TURKU 52,FINLAND
来源：
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1991年 / 41卷 / 01期
关键词：
PIROXICAM; PHARMACOKINETICS; CHILDREN; RHEUMATOID ARTHRITIS;
D O I：
10.1007/BF00280114
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Ten children with rheumatoid arthritis, aged 7-16 y and weighing 20-63 kg, were treated with piroxicam mean dose 0.4 mg . kg-1 once daily for 2 weeks. On Day 15, blood was sampled from 2-120 h after the last dose. The C(max) for piroxicam ranged from 3.6 to 9.8 (mean 6.6) mg . l-1 and its half-life by log linear computation was 22 to 40 (mean 32.6) h. The volumes of distribution and the total body clearance were estimated as the ratio of actual volumes of distribution and actual clearances to availability. The volumes of distribution (V/F) were 0.12 to 0.25 (mean 0.16) l . kg-1, and the total body clearances (CL/F) were 2.1 to 5.0 (mean 3.4) ml . kg-1 . h-1. Thus, piroxicam clearance in these patients was higher and its half-life was shorter than those previously reported in young adults, yet V appeared similar.
引用
收藏
页码：79 / 81
页数：3
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