STEADY-STATE PHARMACOKINETICS OF PIROXICAM IN CHILDREN WITH RHEUMATIC DISEASES

被引：11
作者：
MAKELA, AL
OLKKOLA, KT
MATTILA, MJ
机构：
[1] UNIV HELSINKI,DEPT CLIN PHARMACOL,SF-00170 HELSINKI 17,FINLAND
[2] UNIV TURKU,CENT HOSP,DEPT PEDIAT,SF-20520 TURKU 52,FINLAND
来源：
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1991年 / 41卷 / 01期
关键词：
PIROXICAM; PHARMACOKINETICS; CHILDREN; RHEUMATOID ARTHRITIS;
D O I：
10.1007/BF00280114
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Ten children with rheumatoid arthritis, aged 7-16 y and weighing 20-63 kg, were treated with piroxicam mean dose 0.4 mg . kg-1 once daily for 2 weeks. On Day 15, blood was sampled from 2-120 h after the last dose. The C(max) for piroxicam ranged from 3.6 to 9.8 (mean 6.6) mg . l-1 and its half-life by log linear computation was 22 to 40 (mean 32.6) h. The volumes of distribution and the total body clearance were estimated as the ratio of actual volumes of distribution and actual clearances to availability. The volumes of distribution (V/F) were 0.12 to 0.25 (mean 0.16) l . kg-1, and the total body clearances (CL/F) were 2.1 to 5.0 (mean 3.4) ml . kg-1 . h-1. Thus, piroxicam clearance in these patients was higher and its half-life was shorter than those previously reported in young adults, yet V appeared similar.
引用
收藏
页码：79 / 81
页数：3
相关论文
共 50 条
[21]   Population pharmacokinetics of steady-state carbamazepine in Egyptian epilepsy patients [J].
EL Desoky, E. S. ;
Sabarinath, S. N. ;
Hamdi, M. M. ;
Bewernitz, M. ;
Derendorf, H. .
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2012, 37 (03) :352-355
[22]   Effects of steady-state clarithromycin on the pharmacokinetics of zolpidem in healthy subjects [J].
Lee, Choong-Min ;
Jung, Eui Hyun ;
Byeon, Ji-Yeong ;
Kim, Se-Hyung ;
Jang, Choon-Gon ;
Lee, Yun Jeong ;
Lee, Seok-Yong .
ARCHIVES OF PHARMACAL RESEARCH, 2019, 42 (12) :1101-1106
[23]   STEADY-STATE PHARMACOKINETICS OF IDEBENONE IN PATIENTS WITH MODERATE HEPATIC IMPAIRMENT [J].
COTO, V ;
OLIVIERO, U ;
SORRENTINO, P ;
COCOZZA, M ;
DEPAOLA, P ;
LINGETTI, M .
ARCHIVES OF GERONTOLOGY AND GERIATRICS, 1992, 15 (03) :207-214
[24]   Effect of steady-state etravirine on the pharmacokinetics and pharmacodynamics of ethinylestradiol and norethindrone [J].
Scholler-Gyure, Monika ;
Kakuda, Thomas N. ;
Woodfall, Brian ;
Aharchi, Fatima ;
Peeters, Monika ;
Vandermeulen, Kati ;
Hoetelmans, Richard M. W. .
CONTRACEPTION, 2009, 80 (01) :44-52
[25]   Irbesartan does not affect the steady-state pharmacodynamics and pharmacokinetics of warfarin [J].
B. Mangold ;
W. Gielsdorf ;
M. R. Marino .
European Journal of Clinical Pharmacology, 1999, 55 :593-598
[26]   Determinants of steady-state mycophenolate mofetil pharmacokinetics in lupus patients [J].
Djabarouti, S. ;
Legeron, R. ;
Saux, M. -C. ;
Breilh, D. .
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY, 2011, 33 (02) :318-319
[27]   Effects of steady-state clarithromycin on the pharmacokinetics of zolpidem in healthy subjects [J].
Choong-Min Lee ;
Eui Hyun Jung ;
Ji-Yeong Byeon ;
Se-Hyung Kim ;
Choon-Gon Jang ;
Yun Jeong Lee ;
Seok-Yong Lee .
Archives of Pharmacal Research, 2019, 42 :1101-1106
[28]   INITIAL AND STEADY-STATE PHARMACOKINETICS OF A VAGINALLY ADMINISTERED FORMULATION OF PROGESTERONE [J].
ARCHER, DF ;
FAHY, GE ;
VINIEGRASIBAL, A ;
ANDERSON, FD ;
SNIPES, W ;
FOLDESY, RG .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1995, 173 (02) :471-478
[29]   Irbesartan does not affect the steady-state pharmacodynamics and pharmacokinetics of warfarin [J].
Mangold, B ;
Gielsdorf, W ;
Marino, MR .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1999, 55 (08) :593-598
[30]   Effects of erythromycin at steady-state concentrations on the pharmacokinetics of ulipristal acetate [J].
Pohl, O. ;
Osterloh, I. ;
Gotteland, J-P .
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2013, 38 (06) :512-517
12345