CHARACTERIZATION OF THE PROMOTER REGION OF HUMAN BCL-6 GENE

被引：22

作者：

OHASHI, K ^{[1
]}

MIKI, T ^{[1
]}

HIROSAWA, S ^{[1
]}

AOKI, N ^{[1
]}

机构：

[1] TOKYO MED & DENT UNIV,DEPT INTERNAL MED 1,BUNKYO KU,TOKYO 113,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 214卷 / 02期

关键词：

D O I：

10.1006/bbrc.1995.2309

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The BCL-6 gene encodes a zinc finger-transcription factor and frequently is rearranged in diffuse large cell lymphoma. We have reported here the isolation of the 5'-flanking region of the human BCL-6 gene. Nucleotides sequence of 1.5 Kb promoter region contains TATA box but no CAAT box and a number of potential regulatory elements including CACCC, E-box, and GATA-1 sites. Studies of the promoter activity showed the first 657 nucleotides of the 5'-flanking region significantly drove transcription of the luciferase reporter gene in human Burkitt's lymphoma cell line. (C) 1995 Academic Press, Inc.

引用

页码：461 / 467

页数：7

共 18 条

[1] IDENTIFICATION OF THE GENE ASSOCIATED WITH THE RECURRING CHROMOSOMAL TRANSLOCATIONS T(3,14)(Q27,Q32) AND T(3,22)(Q27,Q11) IN B-CELL LYMPHOMAS
BARON, BW
NUCIFORA, G
MCCABE, N
ESPINOSA, R
LEBEAU, MM
MCKEITHAN, TW
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (11) : 5262 - 5266
[2] DIFFERENCES AND SIMILARITIES IN DNA-BINDING PREFERENCES OF MYOD AND E2A PROTEIN COMPLEXES REVEALED BY BINDING-SITE SELECTION
BLACKWELL, TK
WEINTRAUB, H
[J]. SCIENCE, 1990, 250 (4984) : 1104 - 1110
[3] EXPRESSION OF A SINGLE TRANSFECTED CDNA CONVERTS FIBROBLASTS TO MYOBLASTS
DAVIS, RL
WEINTRAUB, H
LASSAR, AB
[J]. CELL, 1987, 51 (06) : 987 - 1000
[4] E-BOX-INDEPENDENT AND MEF-2-INDEPENDENT MUSCLE-SPECIFIC EXPRESSION, POSITIVE AUTOREGULATION, AND CROSS-ACTIVATION OF THE CHICKEN MYOD (CMD1) PROMOTER REVEAL AN INDIRECT REGULATORY PATHWAY
DECHESNE, CA
WEI, Q
ELDRIDGE, J
GANNOUNZAKI, L
MILLASSEAU, P
BOUGUELERET, L
CATERINA, D
PATERSON, BM
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (08) : 5474 - 5486
[5] CLONING OF A BREAKPOINT CLUSTER REGION AT BAND 3Q27 INVOLVED IN HUMAN NON-HODGKINS-LYMPHOMA
DEWEINDT, C
KERCKAERT, JP
TILLY, H
QUIEF, S
NGUYEN, VC
BASTARD, C
[J]. GENES CHROMOSOMES & CANCER, 1993, 8 (03) : 149 - 154
[6] CONTROL OF EUKARYOTIC MESSENGER-RNA SYNTHESIS BY SEQUENCE-SPECIFIC DNA-BINDING PROTEINS
DYNAN, WS
TJIAN, R
[J]. NATURE, 1985, 316 (6031) : 774 - 778
[7] TRANSCRIPTION FACTOR AP-2 MEDIATES INDUCTION BY 2 DIFFERENT SIGNAL-TRANSDUCTION PATHWAYS - PROTEIN-KINASE-C AND CAMP
IMAGAWA, M
CHIU, R
KARIN, M
[J]. CELL, 1987, 51 (02) : 251 - 260
[8] RECOGNITION DNA-SEQUENCE OF A NOVEL PUTATIVE TRANSCRIPTION FACTOR, BCL6
KAWAMATA, N
MIKI, T
OHASHI, K
SUZUKI, K
FUKUDA, T
HIROSAWA, S
AOKI, N
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 204 (01) : 366 - 374
[9] KAWAMATA N, 1994, LEUKEMIA, V8, P1327
[10] LAZ3, A NOVEL ZINC-FINGER ENCODING GENE, IS DISRUPTED BY RECURRING CHROMOSOME-3Q27 TRANSLOCATIONS IN HUMAN LYMPHOMAS
KERCKAERT, JP
DEWEINDT, C
TILLY, H
QUIEF, S
LECOCQ, G
BASTARD, C
[J]. NATURE GENETICS, 1993, 5 (01) : 66 - 70

← 1 2 →