FIBRILS FROM SYNTHETIC AMYLOID-RELATED PEPTIDES ENHANCE DEVELOPMENT OF EXPERIMENTAL AA-AMYLOIDOSIS IN MICE

被引：80

作者：

GANOWIAK, K ^{[1
]}

HULTMAN, P ^{[1
]}

ENGSTROM, U ^{[1
]}

GUSTAVSSON, A ^{[1
]}

WESTERMARK, P ^{[1
]}

机构：

[1] LUDWIG INST CANC RES,UPPSALA BRANCH,UPPSALA,SWEDEN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 199卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.1229

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Amyloid enhancing factor is an incompletely characterized activity of extracts from many amyloid-containing tissues and which greatly shortens the preamyloidotic phase during experimental induction of AA-amyloidosis. In this communication we show that amyloid-like fibrils made in vitro from synthetic peptides, corresponding to segments of amyloid fibril proteins, have amyloid enhancing factor-like activity. Thus, there is a possibility that amyloid enhancing factor activity depends on small fibrils serving as nucleation centers for fibril elongation. (C) 1994 Academic Press, Inc.

引用

页码：306 / 312

页数：7

共 19 条

[1] A KINETIC-MODEL FOR AMYLOID FORMATION IN THE PRION DISEASES - IMPORTANCE OF SEEDING [J].