INHIBITION BY VITAMIN-D3 OF ERYTHROID-DIFFERENTIATION OF HUMAN LEUKEMIA LINE CELLS INDUCED BY TRANSFORMING GROWTH-FACTOR-BETA OR ERYTHROID-DIFFERENTIATION FACTOR (ACTIVIN-A)

被引：11

作者：

OKABEKADO, J

HONMA, Y

HOZUMI, M

机构：

[1] Department of Chemotherapy, Saitama Cancer Center Research Institute, Kitaadachigun, Saitama, 362, Ina-machi

来源：

LEUKEMIA RESEARCH | 1991年 / 15卷 / 08期

关键词：

ERYTHROID DIFFERENTIATION; LEUKEMIA CELL LINES; TRANSFORMING GROWTH FACTOR-BETA; VITAMIN-D3;

D O I：

10.1016/0145-2126(91)90075-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Erythroid differentiation of human leukemic cell lines (HEL, KU812F and K562) was induced by their treatment with transforming growth factor-beta (TGF-beta) or erythroid differentiation factor (EDF/Activin A). Their erythroid differentiation was markedly inhibited by vitamin D3, dexamethasone or 12-O-tetradecanoyl-phorbol-13-acetate, which are known to induce monocytic differentiation of leukemic cells. These results suggest that inducers of monocytic differentiation may switch off cellular regulatory mechanisms for induction by TGF-beta and EDF of erythroid differentiation of leukemia cells.

引用

页码：721 / 726

页数：6

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