BASAL RELEASE OF NITRIC-OXIDE FROM AORTIC RINGS IS GREATER IN FEMALE RABBITS THAN IN MALE RABBITS - IMPLICATIONS FOR ATHEROSCLEROSIS

被引：457
作者：
HAYASHI, T
FUKUTO, JM
IGNARRO, LJ
CHAUDHURI, G
机构：
[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT PHARMACOL,LOS ANGELES,CA 90024
[2] UNIV CALIF LOS ANGELES,SCH MED,DEPT OBSTET & GYNECOL,LOS ANGELES,CA 90024
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 23期
关键词：
ENDOTHELIUM-DERIVED RELAXING FACTOR; SUPEROXIDE DISMUTASE; L-ARGININE; GENDER DIFFERENCE; ESTROGEN;
D O I：
10.1073/pnas.89.23.11259
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Estradiol is known to exert a protective effect against the development of atherosclerosis, but the mechanism of this hormonal action is unknown. One of the early events in the development of atherosclerosis is the adhesion of macrophages to endothelial cells, and nitric oxide (NO) inhibits this process. We show that basal release of NO is greater with endothelium-intact aortic rings from female rabbits than those from males. Oophorectomy diminishes both circulating estradiol concentration and basal release of NO to levels seen in male rabbits. These data establish that basal NO release from endothelium-intact aortic rings depends on circulating estradiol concentration and offer an explanation for the protective effect of estradiol against the development of atherosclerosis.
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页码：11259 / 11263
页数：5
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