ENHANCEMENT OF THE ANTI-HIV-1 ACTIVITY OF 2',3'-DIDEHYDRO-2',3'-DIDEOXYTHYMIDINE (D4T) BY THE THYMIDYLATE SYNTHETASE INHIBITOR FUDR - AN ANTI-HIV STRATEGY WITH A HOST-CELL TARGET

被引：0
|
作者：
GAO, WY
JOHNS, DG
AHLUWALIA, G
MITSUYA, H
机构：
[1] NCI,DTP,MED CHEM LAB,BETHESDA,MD 20892
[2] NCI,DTP,MED BRANCH,EXPTL RETROVIROL SECT,BETHESDA,MD 20892
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 1995年 / 11卷
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
引用
收藏
页码：S161 / S161
页数：1
相关论文
共 50 条
  • [1] SYNTHESIS, ANTI-HIV ACTIVITY, AND BIOLOGICAL PROPERTIES OF 2',3'-DIDEHYDRO-2',3'-DIDEOXYTHYMIDINE (D4T)
    MARTIN, JC
    MANSURI, MM
    STARRETT, JE
    SOMMADOSSI, JP
    BRANKOVAN, V
    GHAZZOULI, I
    HO, HT
    HITCHCOCK, MJM
    NUCLEOSIDES & NUCLEOTIDES, 1989, 8 (5-6): : 841 - 844
  • [2] STRUCTURAL STUDIES OF THE ANTI-HIV AGENT 2',3'-DIDEHYDRO-2',3'-DIDEOXYTHYMIDINE (D4T)
    HARTE, WE
    STARRETT, JE
    MARTIN, JC
    MANSURI, MM
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 175 (01) : 298 - 304
  • [3] MEASUREMENT OF THE ANTI-HIV AGENT 2',3'-DIDEHYDRO-2',3'-DIDEOXYTHYMIDINE (D4T) BY COMPETITIVE ELISA
    FERRUA, B
    TRAN, TT
    QUARANTA, JF
    KUBAR, J
    ROPTIN, C
    CONDOM, R
    DURANT, J
    GUEDJ, R
    JOURNAL OF IMMUNOLOGICAL METHODS, 1994, 176 (01) : 103 - 110
  • [4] SYNTHESIS AND ANTI-HIV ACTIVITY OF 3'-CYANO-2',3'-DIDEOXYTHYMIDINE AND 3'-CYANO-2',3'-DIDEHYDRO-2',3'-DIDEOXYTHYMIDINE
    MATSUDA, A
    SATOH, M
    NAKASHIMA, H
    YAMAMOTO, N
    UEDA, T
    HETEROCYCLES, 1988, 27 (11) : 2545 - 2548
  • [5] SUPPRESSION OF MURINE RETROVIRAL DISEASE BY 2',3'-DIDEHYDRO-2',3'-DIDEOXYTHYMIDINE (D4T)
    SIDWELL, RW
    HITCHCOCK, M
    OKLEBERRY, KM
    BURGER, RA
    WARREN, RP
    MORREY, JD
    ANTIVIRAL RESEARCH, 1992, 19 (04) : 313 - 324
  • [6] Asymmetric synthesis and anti-HIV activity of 1-carbocyclic 2′,3′-didehydro-2′,3′-dideoxyadenosine
    Wang, PY
    Schinazi, RF
    Chu, CK
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (13) : 1585 - 1588
  • [7] Synthesis and anti-HIV activity of some novel arylphosphate and H-phosphonate derivatives of 3′-azido-2′,3′-dideoxythymidine and 2′,3′-didehydro-2′,3′-dideoxythymidine
    Cardona, VMF
    Ayi, AI
    Aubertin, AM
    Guedj, R
    ANTIVIRAL RESEARCH, 1999, 42 (03) : 189 - 196
  • [8] Synthesis and spectroscopic analysis of 2′,3′-didehydro-2′,3′-dideoxythymidine (d4T) 5′-thiophosphoramidates
    Miao, ZW
    Feng, YP
    Fu, H
    Tu, GZ
    Zhao, YF
    ACTA CHIMICA SINICA, 2002, 60 (10) : 1887 - 1892
  • [9] A HIGHLY STEREOSELECTIVE SYNTHESIS OF ANTI-HIV 2',3'-DIDEOXYNUCLEOSIDES AND 2',3'-DIDEHYDRO-2',3'-DIDEOXYNUCLEOSIDES
    BEACH, JW
    KIM, HO
    JEONG, LS
    NAMPALLI, S
    ISLAM, Q
    AHN, SK
    BABU, JR
    CHU, CK
    JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (14): : 3887 - 3894
  • [10] THE ANTI-HTLV-III (ANTI-HIV) AND CYTOTOXIC ACTIVITY OF 2',3'-DIDEHYDRO-2',3'-DIDEOXYRIBONUCLEOSIDES - A COMPARISON WITH THEIR PARENTAL 2',3'-DIDEOXYRIBONUCLEOSIDES
    BALZARINI, J
    KANG, GJ
    DALAL, M
    HERDEWIJN, P
    DECLERCQ, E
    BRODER, S
    JOHNS, DG
    MOLECULAR PHARMACOLOGY, 1987, 32 (01) : 162 - 167
12345