CONSTITUENTS AND CYTOTOXIC PRINCIPLES OF NOTHAPODYTES FOETIDA

被引：55
作者：
WU, TS
LEU, YL
HSU, HC
OU, LF
CHEN, CC
CHEN, CF
OU, JC
WU, YC
机构：
[1] NATL RES INST CHINESE MED,TAIPEI,TAIWAN
[2] KAOHSIUNG MED COLL,SCH PHARM,KAOHSIUNG,TAIWAN
来源：
PHYTOCHEMISTRY | 1995年 / 39卷 / 02期
关键词：
NOTHAPODYTES FOETIDA; ICACINACEAE; CAMPTOTHECINS; STEROIDS; CYTOTOXICITY;
D O I：
10.1016/0031-9422(94)00901-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new naturally occurring alkaloid, acetylcamptothecin, together with 17 known compounds, (+)-1-hydroxypinoresinol, omega-hydroxypropioguaiacone, p-hydroxybenzaldehyde, scopoletin, uracil, thymine, sitosterol, sitosteryl-beta-D-glucoside, 3 beta-hydroxy-stigmast-5-en-7-one, stigmast-5-en-3 beta,7 alpha-diol, 6 beta-hydroxystigmast-4-en-3-one, sitost-4-en-3-one, linoleic acid, trigonelline, camptothecin, 9-O-methoxycamptothecin and pumiloside were isolated and characterized from the stem of Nothapodytes-foetida. Among them, scopoletin, camptothecin, 9-O-methoxycamptothecin and O-acetylcamptothecin showed significant cytotoxic activity.
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页码：383 / 385
页数：3
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