EXTRACTIVE COLORIMETRIC DETERMINATION OF IRON(III) IN PHARMACEUTICAL FORMULATIONS BY MEANS OF TRIFLUOROACETYLACETONE

被引：10

作者：

RAGGI, MA

NOBILE, L

PERBONI, I

RAMINI, M

机构：

[1] Department of Pharmaceutical Sciences, University of Bologna, Bologna

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 61卷 / 03期

关键词：

Complexation reaction; Extractive colorimetric analysis; Fe(III) assay; Ferric trifluoroacetylacetonate complex; Iron(III); Iron-containing pharmaceutical;

D O I：

10.1016/0378-5173(90)90209-M

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A colorimetric procedure for the determination of iron(III) in pharmaceutical formulations is proposed. It is based on the complexation reaction between the metal ion and trifluoroacetylacetone (Htfa) and on the extraction in n-hexane of the complex Fe(tfa)3 formed. This complex is intensely coloured and allows the assay of iron in the range 1.5-30 ppm. The optimal experimental conditions were: pH = 1, [Htfa]/[Fe] = 1000, time of heating = 50 min at 60°C, λ = 435 nm. The method, applied to various pharmaceutical preparations, proved suitable, in terms of accuracy and precision, for iron(III) determination. © 1990.

引用

页码：199 / 203

页数：5

共 10 条

[1]

BARAN E J, 1988, Acta Farmaceutica Bonaerense, V7, P33

[2] A STUDY OF THE VOLATILE CHARACTERISTICS OF VARIOUS METAL BETA-DIKETONE CHELATES [J].