NK-1 RECEPTORS MEDIATE THE TACHYKININ STIMULATION OF SALIVARY SECRETION - SELECTIVE AGONISTS PROVIDE FURTHER EVIDENCE

被引：32
作者：
GIULIANI, S
MAGGI, CA
REGOLI, D
DRAPEAU, G
ROVERO, P
MELI, A
机构：
[1] A MENARINI PHARMACEUT, DEPT PHARMACOL, RES LABS, VIA SETTE SANTI 3, I-50131 FLORENCE, ITALY
[2] MENARINI PHARMACEUT, DEPT CHEM, FLORENCE, ITALY
[3] UNIV SHERBROOKE, DEPT PHYSIOL & PHARMACOL, SHERBROOKE J1K 2R1, QUEBEC, CANADA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1988年 / 150卷 / 03期
关键词：
D O I：
10.1016/0014-2999(88)90022-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The relative contribution of NK-1, NK-2 and NK-3 receptors to the sialogogic response to i.v. tachykinins was investigated in urethane-anesthetized rats. [Pro9,Met(O2)11] substance P (SP), a selective NK-1 receptor agonist, was about 10 times more potent than SP itself and its action was unaffected by atropine pretreatment. On the other hand [Nle10]neurokinin A (NKA)-(4-10) and [MePhe7]neurokinin B (NKB), two selective agonists for NK-2 and NK-3 receptors, respectively, were ineffective.
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页码：377 / 379
页数：3
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