PRODUCTION OF PARATHYROID-HORMONE-RELATED PROTEIN BY CHOLESTEATOMA CELLS IN CULTURE

被引：20
作者：
CHESHIRE, IM
BLIGHT, A
RATCLIFFE, WA
PROOPS, DW
HEATH, DA
机构：
[1] QUEEN ELIZABETH HOSP,WOLFSON RES LABS,BIRMINGHAM B15 2TH,W MIDLANDS,ENGLAND
[2] QUEEN ELIZABETH HOSP,DEPT OTOLARYNGOL,BIRMINGHAM B15 2TH,W MIDLANDS,ENGLAND
[3] QUEEN ELIZABETH HOSP,DEPT MED,BIRMINGHAM B15 2TH,W MIDLANDS,ENGLAND
来源：
LANCET | 1991年 / 338卷 / 8774期
关键词：
D O I：
10.1016/0140-6736(91)91902-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Specimens of cholesteatoma were removed at surgery from five patients who had evidence of bone resorption. Parathyroid-hormone-related protein (PTHrP) was detected, by radioimmunoassay, in conditioned media from keratinocyte cultures derived from all five samples. Concentrations of PTHrP in conditioned media from secondary cultures were higher for the cholesteatoma cells than for normal keratinocytes from controls matched for age and sex. Thus, production of PTHrP by cholesteatoma may be a contributory factor in the bone destruction commonly associated with this disorder.
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页码：1041 / 1043
页数：3
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