PROOXIDANT EFFECTS OF 7-HYDROPEROXYCHOLEST-5-EN-3-BETA-OL ON THE COPPER-INITIATED OXIDATION OF LOW-DENSITY-LIPOPROTEIN

被引：18

作者：

BLACHE, D ^{[1
]}

RODRIGUEZ, C ^{[1
]}

DAVIGNON, J ^{[1
]}

机构：

[1] INST RECH CLIN MONTREAL,DEPT RECH LIPIDES & ATHEROSCLEROSE,MONTREAL,PQ H2W 1R7,CANADA

来源：

FEBS LETTERS | 1995年 / 357卷 / 02期

基金：

英国医学研究理事会;

关键词：

CHOLESTEROL HYDROPEROXIDE; AGED CHOLESTEROL; OXYSTEROL; OXIDIZED LDL; OXIDATION; COPPER;

D O I：

10.1016/0014-5793(94)01348-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In low density lipoproteins (LDL) supplemented with aged cholesterol and oxidized in the presence of Cu2+, an increase of the lipid oxidation parameters was observed compared with pure cholesterol-enriched LDL. A compound, identified as 7-hydroperoxycholesterol (7HPC), isolated from aged cholesterol and added to LDL, reproduced the above effects. The results indicate that the pro-oxidant effect of 7HPC is dependent on the hydroperoxy group since the corresponding alcohol derivative, 7 alpha-hydroxycholesterol, had no such effect. These data suggest that among the LDL-associated lipid peroxides, cholesterol peroxides may have important implications in the susceptibility of this lipoprotein to oxidation.

引用

页码：135 / 139

页数：5

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