GERM-LINE P53 MUTATION IS UNCOMMON IN PATIENTS WITH TRIPLE PRIMARY CANCERS

被引:24
|
作者
SHISEKI, M
NISHIKAWA, R
YAMAMOTO, H
OCHIAI, A
SUGIMURA, H
SHITARA, N
SAMESHIMA, Y
MIZOGUCHI, H
SUGIMURA, T
YOKOTA, J
机构
[1] NATL CANC CTR, RES INST, DIV BIOL, 1-1 TSUKIJI 5 CHOME, CHUO KU, TOKYO 104, JAPAN
[2] TOKYO WOMENS MED COLL, DEPT HEMATOL, SHINJUKU KU, TOKYO 162, JAPAN
[3] NATL CANC CTR, CHUO KU, TOKYO 104, JAPAN
[4] NATL CANC CTR, RES INST, DIV PATHOL, CHUO KU, TOKYO 104, JAPAN
[5] HAMAMATSU UNIV SCH MED, HAMAMATSU, SHIZUOKA 43131, JAPAN
[6] KOMAGOME METROPOLITAN HOSP, BUNKYO KU, TOKYO 113, JAPAN
关键词
LI-FRAUMENI SYNDROME; GERM-LINE P53 MUTATION; MULTIPLE PRIMARY CANCERS; TUMOR SUPPRESSOR GENE;
D O I
10.1016/0304-3835(93)90187-E
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We examined five patients with multiple primary cancers who had a history of three different types of primary cancers for germ-line p53 mutations. The germ-line p53 mutation was detected in a patient who conformed to the Li-Fraumeni syndrome, but not in the other four patients. The diagnosis of these four patients did not fall in the category of Li-Fraumeni syndrome. This result indicates that germ-line p53 mutations are uncommon even in patients with triple primary cancers.
引用
收藏
页码:51 / 57
页数:7
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