GERM-LINE P53 MUTATION IS UNCOMMON IN PATIENTS WITH TRIPLE PRIMARY CANCERS

被引：24

作者：

SHISEKI, M

NISHIKAWA, R

YAMAMOTO, H

OCHIAI, A

SUGIMURA, H

SHITARA, N

SAMESHIMA, Y

MIZOGUCHI, H

SUGIMURA, T

YOKOTA, J

机构：

[1] NATL CANC CTR, RES INST, DIV BIOL, 1-1 TSUKIJI 5 CHOME, CHUO KU, TOKYO 104, JAPAN

[2] TOKYO WOMENS MED COLL, DEPT HEMATOL, SHINJUKU KU, TOKYO 162, JAPAN

[3] NATL CANC CTR, CHUO KU, TOKYO 104, JAPAN

[4] NATL CANC CTR, RES INST, DIV PATHOL, CHUO KU, TOKYO 104, JAPAN

[5] HAMAMATSU UNIV SCH MED, HAMAMATSU, SHIZUOKA 43131, JAPAN

[6] KOMAGOME METROPOLITAN HOSP, BUNKYO KU, TOKYO 113, JAPAN

来源：

CANCER LETTERS | 1993年 / 73卷 / 01期

关键词：

LI-FRAUMENI SYNDROME; GERM-LINE P53 MUTATION; MULTIPLE PRIMARY CANCERS; TUMOR SUPPRESSOR GENE;

D O I：

10.1016/0304-3835(93)90187-E

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined five patients with multiple primary cancers who had a history of three different types of primary cancers for germ-line p53 mutations. The germ-line p53 mutation was detected in a patient who conformed to the Li-Fraumeni syndrome, but not in the other four patients. The diagnosis of these four patients did not fall in the category of Li-Fraumeni syndrome. This result indicates that germ-line p53 mutations are uncommon even in patients with triple primary cancers.

引用

页码：51 / 57

页数：7

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