URINARY-EXCRETION OF RENIN AND ANGIOTENSINOGEN IN NEPHROTIC RATS

被引：13
|
作者：
PEDRAZACHAVERRI, J [1 ]
CRUZ, C [1 ]
IBARRARUBIO, ME [1 ]
HERNANDEZ, C [1 ]
TAPIA, E [1 ]
PENA, JC [1 ]
机构：
[1] INST NACL CARDIOL IGNACIO CHAVEZ, DEPT NEFROL, MEXICO CITY, MEXICO
来源：
NEPHRON | 1991年 / 57卷 / 01期
关键词：
D O I：
10.1159/000186226
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Puromycin aminonucleoside (PA)-nephrotic rats have a high plasma renin activity (PRA) and low angiotensinogen levels. We measured proteinuria, urine renin, and urine angiotensinogen daily, for 11 days after PA injection. Proteinuria and urine angiotensinogen were evident on day 5, and urine renin on day 6. Peak levels of urine renin and angiotensinogen were attained on day 8. These data suggest that angiotensinogen urine excretion may contribute to its low plasma levels, and urine renin loss may limit a further increase in PRA.
引用
收藏
页码：106 / 108
页数：3
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