Advances in Positive Airway Pressure Treatment Modalities for Hypoventilation Syndromes

Positive airway pressure therapy for hypoventilation syndromes can improve health-related quality of life. Sleep-disordered breathing is complex and requires sophisticated devices to detect and treat respiratory events and reduce the work of breathing while maintaining breathing comfort. Although such devices are increasingly used in clinical practice, supporting clinical evidence-specifically comparative-effectiveness studies in real-life conditions-needs to be gathered. There is opportunity to refine these devices, including the ability of the device to monitor gas exchange and sleep-wakefulness state, and for reducing variability in device efficacy owing to provider-selected device settings.