Biomarker-Based Targeting of the Androgen-Androgen Receptor Axis in Advanced Prostate Cancer

被引：11

作者：

Kohli, Manish

Qin, Rui

Jimenez, Rafael

Dehm, Scott M.

机构：

[1] Department of Oncology, Mayo Clinic, Rochester, MN 55905

[2] Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905

[3] Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905

[4] Masonic Cancer Center, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis

来源：

ADVANCES IN UROLOGY | 2012年 / 2012卷

关键词：

D O I：

10.1155/2012/781459

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Recent therapeutic advances for managing advanced prostate cancer include the successful targeting of the androgen-AR axis with several new drugs in castrate resistant prostate cancer including abiraterone acetate and enzalutamide (MDV3100). This translational progress from "bench to bed-side" has resulted in an enlarging repertoire of novel and traditional drug choices now available for use in advanced prostate cancer therapeutics, which has had a positive clinical impact in prolonging longevity and quality of life of advanced prostate cancer patients. In order to further the clinical utility of these drugs, development of predictive biomarkers guiding individual therapeutic choices remains an ongoing challenge. This paper will summarize the potential in developing predictive biomarkers based on the pathophysiology of the androgen-AR axis in tumor tissue from patients with advanced prostate cancer as well as inherited variation in the patient's genome. Specific examples of rational clinical trial designs incorporating potential predictive biomarkers from these pathways will illustrate several aspects of pharmacogenetic and pharmacogenomic predictive biomarker development in advanced prostate cancer therapeutics.

引用

页数：14

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