TRANSFORMING GROWTH-FACTOR-BETA IN LEISHMANIAL INFECTION - A PARASITE ESCAPE MECHANISM

被引：400
作者：
BARRALNETTO, M
BARRAL, A
BROWNELL, CE
SKEIKY, YAW
ELLINGSWORTH, LR
TWARDZIK, DR
REED, SG
机构：
[1] SEATTLE BIOMED RES INST,SEATTLE,WA 98109
[2] FED UNIV BAHIA,SCH MED,BR-40140 SALVADOR,BA,BRAZIL
[3] CELTRIX LABS INC,PALO ALTO,CA 94303
[4] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,SEATTLE,WA 98121
[5] CORNELL UNIV,MED CTR,COLL MED,NEW YORK,NY 10021
来源：
SCIENCE | 1992年 / 257卷 / 5069期
关键词：
D O I：
10.1126/science.1636092
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The course of infection with the protozoan parasite Leishmania is determined in part by their early replication in macrophages, the exclusive host cells for these organisms. Although factors contributing to the survival of Leishmania are not well understood, cytokines influence the course of infection. Transforming growth factor-beta (TGF-beta) is a multipotential cytokine with diverse effects on cells of the immune system, including down-regulation of certain macrophage functions. Leishmanial infection induced the production of active TGF-beta, both in vitro and in vivo. TGF-beta was important for determining in vivo susceptibility to experimental leishmanial infection.
引用
收藏
页码：545 / 548
页数：4
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