Heart transplantation for cardiac light chain amyloidosis with subsequent autologous stem cell transplantation

被引：0

作者：

Honek, Tomas ^{[1
,2
]}

Krejci, Jan ^{[1
,2
]}

Spinarova, Lenka ^{[1
,2
]}

Hude, Petr ^{[1
,2
]}

Nemec, Petr ^{[3
]}

Adam, Zdenek ^{[2
,4
]}

Sirotkova, Alzbeta ^{[5
]}

Zampachova, Vita ^{[5
]}

Vitovec, Jiri ^{[1
,2
]}

机构：

[1] St Annes Univ Hosp Brno, Int Clin Res Ctr, Dept Cardiovasc Dis, Brno, Czech Republic

[2] Masaryk Univ, Brno, Czech Republic

[3] St Annes Univ Hosp Brno, Int Clin Res Ctr, Ctr Cardiovasc Surg & Transplantat, Brno, Czech Republic

[4] Univ Hosp Brno, Dept Internal Med Hematol & Oncol, Brno, Czech Republic

[5] St Annes Univ Hosp Brno, Dept Pathol Anat 1, Brno, Czech Republic

来源：

COR ET VASA | 2013年 / 55卷 / 05期

关键词：

Heart failure; Amyloidosis; Heart transplantation; Endomyocardial biopsy; Autologous stem cell; transplantation;

D O I：

10.1016/j.crvasa.2012.11.015

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Our report describes a case of 57-year-old man with manifest heart failure on the basis of cardiac amyloidosis, which was detected by endomyocardial biopsy. Due to the heart failure, the patient was unable to undergo myeloablative therapy. We changed our previous decision for conservative therapy of heart failure and the patient underwent heart transplantation. Autologous stem cell transplantation was performed 6 months later. After the successful stem cell transplantation, the serum free light chain lambda levels promptly decreased. One year later, their levels started again to increase. Chemotherapy was therefore initiated. The patient has now completed the seventh cycle of chemotherapy in good condition. The graft function is normal and the latest endomyocardial biopsy revealed no amyloid. (C) 2012 The Czech Society of Cardiology. Published by Elsevier Urban & Partner Sp.zo.o. All rights reserved.

引用

页码：E468 / E473

页数：6

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