INDIRECT ATOMIC-ABSORPTION AND ATOMIC-EMISSION SPECTROMETRIC DETERMINATION OF ANTAZOLINE, HYDRALAZINE AND AMILORIDE HYDROCHLORIDES AND QUININE SULFATE

Ion-association complexes of antazoline HCl [I], hydralazine HCl [II], amiloride HCl [III] and quinine sulphate [IV] with [Co(SCN)(4)](2-) and [Co(NO2)(6)](3-) were precipitated and the excess unreacted cobalt complex was determined. A new method using atomic emission and atomic absorption spectrometry for the determination of the above drugs in pure solutions and pharmaceutical preparations is given. The drugs can be determined in the ranges 0.3-3.0, 0.19-1.96, 0.3-3.0, and 0.78-7.82 mg/25 ml solutions of I, II, III, and IV, respectively, with mean relative standard deviations of 0.65-2.O3% and recovery values of 95.76-101.2% indicating high precision and accuracy.