COMPARATIVE GENOME MAPPING WITH MOBILE PHYSICAL MAP LANDMARKS

被引：16

作者：

BLOCH, CA ^{[1
]}

RODE, CK ^{[1
]}

OBREQUE, V ^{[1
]}

RUSSELL, KY ^{[1
]}

机构：

[1] UNIV MICHIGAN, SCH PUBL HLTH, DEPT EPIDEMIOL, ANN ARBOR, MI 48109 USA

来源：

JOURNAL OF BACTERIOLOGY | 1994年 / 176卷 / 22期

关键词：

D O I：

10.1128/JB.176.22.7121-7125.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We describe a method for comparative macrorestriction mapping of the chromosomes of Escherichia coli strains. In this method, a series of physically tagged E. coli K-12 alleles serve as mobile landmarks for mapping DNAs from other strains. This technique revealed evidence of strain-specific chromosomal additions or deletions in a pathogenic isolate and can be applied to most strains, yielding information on genealogy as well as virulence. In theory, the same strategy can be used to map and compare genomic DNAs from a wide variety of species.

引用

页码：7121 / 7125

页数：5

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