OCTREOTIDE EFFECTS ON ORTHOSTATIC HYPOTENSION IN PATIENTS WITH MULTIPLE SYSTEM ATROPHY - A CONTROLLED-STUDY OF ACUTE ADMINISTRATION

被引：30
作者：
BORDET, R
BENHADJALI, J
DESTEE, A
BELABBAS, A
LIBERSA, C
机构：
[1] CHU LILLE,HOP B,SERV NEUROL A,F-59037 LILLE,FRANCE
[2] CHU LILLE,SERV PHARMACOL HOSP,LILLE,FRANCE
来源：
CLINICAL NEUROPHARMACOLOGY | 1995年 / 18卷 / 01期
关键词：
OCTREOTIDE; ORTHOSTATIC HYPOTENSION; MULTIPLE SYSTEM ATROPHY; PARKINSONISM; NOREPINEPHRINE;
D O I：
10.1097/00002826-199502000-00012
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In nine patients with orthostatic hypotension due to multiple system atrophy, the effects of octreotide (100 mu g s.c.), a somatostatin analogue, on brood pressure (BP), heart rate (HR), and norepinephrine (NE) plasma levels after 60 degrees head up tilt test were evaluated by a randomly controlled study. Octreotide increased supine BP, tilt-test duration (+ 28%), and delay to obtain minimal BP during the 60 degrees head up tilt (+ 50%). Octreotide changed neither HR nor NE plasma levels.
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页码：83 / 89
页数：7
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