OCTREOTIDE EFFECTS ON ORTHOSTATIC HYPOTENSION IN PATIENTS WITH MULTIPLE SYSTEM ATROPHY - A CONTROLLED-STUDY OF ACUTE ADMINISTRATION

被引：30

作者：

BORDET, R

BENHADJALI, J

DESTEE, A

BELABBAS, A

LIBERSA, C

机构：

[1] CHU LILLE,HOP B,SERV NEUROL A,F-59037 LILLE,FRANCE

[2] CHU LILLE,SERV PHARMACOL HOSP,LILLE,FRANCE

来源：

CLINICAL NEUROPHARMACOLOGY | 1995年 / 18卷 / 01期

关键词：

OCTREOTIDE; ORTHOSTATIC HYPOTENSION; MULTIPLE SYSTEM ATROPHY; PARKINSONISM; NOREPINEPHRINE;

D O I：

10.1097/00002826-199502000-00012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In nine patients with orthostatic hypotension due to multiple system atrophy, the effects of octreotide (100 mu g s.c.), a somatostatin analogue, on brood pressure (BP), heart rate (HR), and norepinephrine (NE) plasma levels after 60 degrees head up tilt test were evaluated by a randomly controlled study. Octreotide increased supine BP, tilt-test duration (+ 28%), and delay to obtain minimal BP during the 60 degrees head up tilt (+ 50%). Octreotide changed neither HR nor NE plasma levels.

引用

页码：83 / 89

页数：7

共 15 条

[1]

Armstrong E, 1991, Clin Auton Res, V1, P135, DOI 10.1007/BF01826210

[2]

Bannister R, 1992, AUTONOMIC FAILURE TX, P622

[3] OCTREOTIDE - A REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES, AND THERAPEUTIC POTENTIAL IN CONDITIONS ASSOCIATED WITH EXCESSIVE PEPTIDE SECRETION [J].