METAL-CHELATE-DENDRIMER-ANTIBODY CONSTRUCTS FOR USE IN RADIOIMMUNOTHERAPY AND IMAGING

被引：137

作者：

WU, CC ^{[1
]}

BRECHBIEL, MW ^{[1
]}

KOZAK, RW ^{[1
]}

GANSOW, OA ^{[1
]}

机构：

[1] US FDA,CTR BIOL EVALUAT & RES,BETHESDA,MD 20892

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 03期

关键词：

D O I：

10.1016/0960-894X(94)80014-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Polyamidoamine dendrimers were modified chemically by reaction with DOTA and DTPA type bifunctional metal chelators and were coupled to monoclonal antibody 2E4 without loss of protein immunoreactivity. Both the DTPA- and DOTA-dendrimer-antibody constructs were easily labeled with Y-90, In-111, Bi-212 or cold Gd(III) suggesting use of this dendrimer-macrocycle for mAb guided radiotherapy or imaging.

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页码：449 / 454

页数：6

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