MAPPING OF THE FUNCTIONAL ACTIVE-SITE OF BAEYER-VILLIGERASES BY SUBSTRATE ENGINEERING

被引：40

作者：

KELLY, DR ^{[1
]}

KNOWLES, CJ ^{[1
]}

MAHDI, JG ^{[1
]}

TAYLOR, IN ^{[1
]}

WRIGHT, MA ^{[1
]}

机构：

[1] UNIV KENT, BIOL LAB, CANTERBURY CT2 7NJ, KENT, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 07期

关键词：

D O I：

10.1039/c39950000729

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An active sits model for enzyme catalysed Baeyer-Villiger reactions is proposed and validated by transformation of the tricyclic ketone 6; Baeyer-Villiger reactions (and Baeyer-Villigerases) are classified by the stereochemistry of the hydroxyperoxide intermediate.

引用

页码：729 / 730

页数：2

共 13 条

[1]

ALI S M, 1979, Journal of the Chemical Society Perkin Transactions I, P708, DOI 10.1039/p19790000708

[2] MICROBIOLOGICAL TRANSFORMATIONS .23. A SURPRISING REGIOSELECTIVITY OF MICROBIOLOGICAL BAEYER-VILLIGER OXIDATIONS OF MENTHONE AND DIHYDROCARVONE [J].

ALPHAND, V ;

FURSTOSS, R .

TETRAHEDRON-ASYMMETRY, 1992, 3 (03) :379-382

[3] MICROBIOLOGICAL TRANSFORMATIONS .22. MICROBIOLOGICALLY MEDIATED BAEYER-VILLIGER REACTIONS - A UNIQUE ROUTE TO SEVERAL BICYCLIC GAMMA-LACTONES IN HIGH ENANTIOMERIC PURITY [J].

ALPHAND, V ;

FURSTOSS, R .

JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (04) :1306-1309

[4]

BERGE JM, 1979, SYNTHESIS-STUTTGART, P471

[5] INTRAMOLECULAR THERMAL REARRANGEMENT OF BICYCLO[3.2.0]-HEPTENYL TO BICYCLO[2.2.1]HEPTENYL SYSTEM [J].

BERSON, JA ;

PATTON, JW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1962, 84 (17) :3406-&

[6] ENZYME-CATALYZED BAEYER-VILLIGER OXIDATIONS OF SOME SUBSTITUTED BICYCLO[3.2.0]HEPTANONES [J].

CARNELL, AJ ;

ROBERTS, SM ;

SIK, V ;

WILLETTS, AJ .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1990, (20) :1438-1439

[7] MICROBIAL OXIDATION OF 7ENDO-METHYLBICYCLO[3.2.0]HEPT-2-EN-6-ONE, 7,7-DIMETHYLBICYCLO[3.2.0]HEPT-2-EN-6-ONE AND 2EXO-BROMO-3ENDO-HYDROXY-7,7-DIMETHYLBICYCLO[3.2.0]HEPTAN-6-ONE USING ACINETOBACTER NCIMB-9871 [J].

CARNELL, AJ ;

ROBERTS, SM ;

SIK, V ;

WILLETTS, AJ .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1991, (10) :2385-2389

[8] FREE RADICAL-MEDIATED RING EXPANSION AND RELATED ANNULATIONS [J].

DOWD, P ;

ZHANG, W .

CHEMICAL REVIEWS, 1993, 93 (06) :2091-2115

[9] BIOLOGICAL BAEYER-VILLIGER OXIDATION OF SOME MONOCYCLIC AND BICYCLIC KETONES USING MONOOXYGENASES FROM ACINETOBACTER-CALCOACETICUS NCIMB-9871 AND PSEUDOMONAS-PUTIDA NCIMB-10007 [J].

GAGNON, R ;

GROGAN, G ;

LEVITT, MS ;

ROBERTS, SM ;

WAN, PWH ;

WILLETTS, AJ .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1994, (18) :2537-2543

[10]

Krow G. R., 2004, ORG REACTIONS, V43, P251, DOI DOI 10.1002/0471264180.OR043.03

← 1 2 →