STRUCTURAL REQUIREMENTS FOR RNA EDITING IN HEPATITIS-DELTA VIRUS - EVIDENCE FOR A URIDINE-TO-CYTIDINE EDITING MECHANISM

被引:110
作者
CASEY, JL
BERGMANN, KF
BROWN, TL
GERIN, JL
机构
[1] Division of Molecular Virology, Georgetown University, Rockville, MD 20852
关键词
D O I
10.1073/pnas.89.15.7149
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Hepatitis delta-virus (HDV) nucleotide 1012 is edited from uridine to cytidine in 10-40% of the RNA genomes during replication. This editing event is an important control point in the HDV life cycle because it results in both the packaging of viral RNA and the inhibition of HDV replication. We find that the editing event is highly specific for both the sequences neighboring nucleotide 1012 and the base-paired context of position 1012 within the unbranched rod structure of HDV RNA. Prior studies identified the base transition at nucleotide 1012 but were unable to distinguish between editing of the genomic versus the antigenomic strands [Luo, G. X., Chao, M., Hsieh, S. Y., Sureau, C., Nishikura, K. & Taylor, J. (1990) J. Virol. 64, 1021-1027]. In this study, comparisons of mutations that differentiate between base pairing in genomic and antigenomic RNAs indicate that the genomic strand of HDV is the actual editing substrate. We conclude that the virus uses a uridine to cytidine editing mechanism, which is provided by the host cell.
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收藏
页码:7149 / 7153
页数:5
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