INDIRECT DETERMINATION OF LIDOCAINE BY ATOMIC-ABSORPTION SPECTROPHOTOMETRY

被引：10

作者：

NERIN, C

GARNICA, A

CACHO, J

机构：

[1] INST TECNOL ARAGON,ZARAGOZA,SPAIN

[2] UNIV SARAGOSSA,DEPT QUIM ANALIT,ZARAGOZA,SPAIN

来源：

ANALYTICAL LETTERS | 1991年 / 24卷 / 10期

关键词：

LIDOCAINE; ATOMIC ABSORPTION; ION PAIR COMPLEX FORMATION;

D O I：

10.1080/00032719108053017

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A new procedure for determining lidocaine chlorhydrate is described. The method consists of extracting an ion pair composed of Lidocaine and the inorganic complex Co(SCN)42- into an organic solvent (1,2 dichloroethane), then measure the Co in the organic phase by A.A.S. at 240.7 mm. Optimal experimental conditions concerning pH, Co(SCN)42- concentration, shaking time, phase ratio, number of extractions and linear range for calibration are studied. The method has a standard deviation of 10(-2). Two pharmaceutical preparations containing lidocaine, have been analyzed with very good results.

引用

页码：1847 / 1859

页数：13

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