DETECTION OF EPSTEIN-BARR-VIRUS SEQUENCES IN PRIMARY BRAIN LYMPHOMA WITHOUT IMMUNODEFICIENCY

被引:24
作者
BIGNON, YJ
CLAVELOU, P
RAMOS, F
JOUVET, A
TOMMASI, M
TOURNILHAC, M
DASTUGUE, B
PLAGNE, R
机构
[1] HOP FONTMAURE,NEUROL CLIN,CHAMALIERES,FRANCE
[2] HOP NEUROL & NEUROCHIRURG,ANAT PATHOL LAB,LYONS,FRANCE
[3] INSERM,CJF 8806,BIOCHIM MED LAB,CLERMONT FERRAND,FRANCE
关键词
HODGKINS-DISEASE; AMPLIFICATION; POLYMERASE; DNA;
D O I
10.1212/WNL.41.7.1152
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We searched for Epstein-Barr virus (EBV) sequences by enzymatic DNA amplification in nine primary brain lymphomas from patients without immunodeficiency. We used seven nonlymphoma brain tumors as negative controls, and the Raji cell line as a positive control. We detected EBV DNA, using ethidium bromide-stained-agarose minigel electrophoresis and dot blot hybridization, in the positive control and in only one brain lymphoma tumor; we did not detect EBV DNA in the other tumors. The EBV-positive patient had a second B-cell monoclonal population in the peripheral blood without detectable EBV DNA, suggesting a direct role for EBV in the development of the brain lymphoma.
引用
收藏
页码:1152 / 1153
页数:2
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