A CONVENIENT METHOD FOR CYANATION OF AROMATIC IODO COMPOUNDS

被引：21

作者：

CARR, RM

CABLE, KM

WELLS, GN

SUTHERLAND, DR

机构：

[1] Isotope Chemistry Group, Chemical Development Division, Glaxo Research and Development Limited, Greenford, Middlesex

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1994年 / 34卷 / 09期

关键词：

CYANATION; ARYL IODIDES; C-13; C-14;

D O I：

10.1002/jlcr.2580340910

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A variety of [C-13]-labelled aromatic nitriles have been prepared in good yield from iodoaromatic substrates. Cyanation was achieved by reaction of aryl iodides with a mixture of potassium [C-13]cyanide and copper (I) iodide in an aprotic solvent at high temperature. The use of pre-prepared carbon-labelled copper (I) cyanide was therefore obviated.

引用

页码：887 / 897

页数：11

共 14 条

[1]

A Pongratz, 1927, MONATSH CHEM, V48, P585, DOI DOI 10.1007/BF01518076

[2] MECHANISMS AND MODELS FOR HOMOGENEOUS COPPER MEDIATED LIGAND-EXCHANGE REACTIONS OF THE TYPE - CUNU + ARX-]ARNU + CUX [J].

COUTURE, C ;

PAINE, AJ .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1985, 63 (01) :111-120

[3] CYANATION OF AROMATIC HALIDES [J].

ELLIS, GP ;

ROMNEYALEXANDER, TM .

CHEMICAL REVIEWS, 1987, 87 (04) :779-794

[4]

FIEDRICH K, 1970, CHEM CYANO GROUP, P67

[5] DIMETHYLFORMAMIDE AS A USEFUL SOLVENT IN PREPARING NITRILES FROM ARYL HALIDES AND CUPROUS CYANIDE - IMPROVED ISOLATION TECHNIQUES [J].

FRIEDMAN, L ;

SHECHTER, H .

JOURNAL OF ORGANIC CHEMISTRY, 1961, 26 (07) :2522-&

[6] SYNTHESIS OF NICOTINIC ACID-7-C-13 [J].

MEINERT, MC ;

NUNEZ, HA ;

BYERRUM, RU .

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1978, 14 (06) :893-896

[7] THE PREPARATION OF NITRILES [J].

MOWRY, DT .

CHEMICAL REVIEWS, 1948, 42 (02) :189-283

[8] N-METHYLPYRROLIDONE AS SOLVENT FOR REACTION OF ARYL HALIDES WITH CUPROUS CYANIDE [J].

NEWMAN, MS ;

BODEN, H .

JOURNAL OF ORGANIC CHEMISTRY, 1961, 26 (07) :2525-&

[9]

Pongratz A., 1929, MONATSH CHEM, V52, P7

[10]

Rosenmund K.W., 1919, CHEM BER-RECL, V52, P1749

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