ARTIFICIAL COLLOIDS IN FLUID RESUSCITATION OF HYPOVOLEMIC SHOCK

Based on the controversy >>crystalloids vs. colloids<< in fluid resuscitation of hypovolemia the pathophysiological background of shock is discussed. Due to listing the goals of shock therapy pharmacodynamic and pharmacocinetic properties of all available, but of newer preparations of blood substitutes too, are defined. Finally special points for a rationale basis of fluid therapy in hypovolemia are explored. Recommendations for administering colloids and crystalloids in hypovolemic shock are: synthetic colloids should be given in therapy of hypovolemia, in disorders of blood fluidity and in situations when oxygen transport capacity of blood has to be improved. Crystalloids should be administered if intracellular and/or interstitial volume deficits have to be replaced.