ASSESSMENT OF HYPOTHALAMIC-PITUITARY FUNCTION IN PATIENTS WITH FAMILIAL AMYLOIDOTIC POLYNEUROPATHY

被引：9
作者：
OLOFSSON, BO
GRANKVIST, K
OLSSON, T
BOMAN, K
FORSBERG, K
LAFVAS, I
LITHNER, F
机构：
[1] CTY HOSP SKELLEFTEA,DEPT INTERNAL MED,SKELLEFTEA,SWEDEN
[2] UMEA UNIV,DEPT INTERNAL MED,S-90187 UMEA,SWEDEN
[3] UMEA UNIV,DEPT CLIN PHARMACOL,S-90187 UMEA,SWEDEN
来源：
JOURNAL OF INTERNAL MEDICINE | 1991年 / 229卷 / 01期
关键词：
ARGININE VASOPRESSIN; FAMILIAL AMYLOIDOSIS; GROWTH HORMONE; HYPOTHALAMIC-PITUITARY REGULATION; PROLACTIN;
D O I：
10.1111/j.1365-2796.1991.tb00306.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This study was performed to evaluate hypothalamic-pituitary hormone regulation in patients with familial amyloidotic polyneuropathy. Twenty-two patients without clinically overt endocrinological dysfunction were studied. A thyrotropin-releasing hormone test revealed abnormal growth hormone regulation in 9 of 17 (53 %) patients, and abnormal prolactin regulation in 9 of 18 (50 %) patients. Abnormalities in either growth hormone or prolactin regulation were found in 12 of 17 (71 %) patients. Serum somatomedin C levels were normal in all 22 patients. In 3 of 18 (17 %) patients the plasma arginine vasopressin levels were low relative to the serum osmolality levels. Thus abnormalities in hypothalamic-pituitary hormone regulation may be common in familial amyloidotic polyneuropathy.
引用
收藏
页码：55 / 59
页数：5
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