Diffusion-tensor imaging in stem cell transplantation associated microangiopathy

被引：0

作者：

Mentzel, Hans-Joachim ^{[1
]}

Kentouche, Karim ^{[2
]}

Guellmar, Daniel ^{[3
]}

Reichenbach, Juergen R. ^{[3
]}

Gruhn, Bernd ^{[2
]}

Kaiser, Werner A. ^{[1
]}

机构：

[1] Friedrich Schiller Univ, Inst Diagnost & Intervent Radiol, Dept Pediat Radiol, Bachstr 18, D-07740 Jena, Germany

[2] Friedrich Schiller Univ, Dept Pediat, Jena, Germany

[3] Friedrich Schiller Univ, Inst Diagnost & Intervent Radiol, Med Phys Grp, Jena, Germany

来源：

JOURNAL OF PEDIATRIC NEUROLOGY | 2007年 / 5卷 / 03期

关键词：

Magnetic resonance imaging; diffusion tensor imaging; fractional anisotropy; apparent diffusion coefficient; tacrolimus; thrombotic thrombocytopenic purpura; stem cell transplantation;

D O I：

暂无

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We describe changes in apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in tacrolimus associated encephalopathy. ADC was clearly increased and FA decreased in the involved regions. There was a strong local contrast-enhancing effect along the cortical surface. Repeat magnetic resonance imaging five days later showed an increase in FA; but no contrast enhancement. The observed ADC and FA changes in the acute phase suggest that vasogenic edema may play a pivotal role in tacrolimus induced neurotoxicity. The contrast-effect can be explained by disturbed venous drainage caused by thrombotic microangiopathy.

引用

页码：233 / 238

页数：6

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